Maurice

Purity, identity and heterogeneity

Maurice gives you reproducible, quantitative analysis of identity, purity, and heterogeneity profiles for your biopharmaceuticals. You'll get IgG purity data in 35 minutes and charge heterogeneity in 10 minutes flat. How's that for fast? And when you want to switch between applications, just change the cartridge—it's that simple. Because all the fluid paths are separate, there's no cross-contamination either.

Maurice

Need cIEF and CE-SDS data for your biologics? Maurice does it all—mAbs, ADCs and vaccines or virus-like particles. He'll even give you data on their variants. Just pop in one of his ready-to-go cartridges, drop in your sample vials or a 96-well plate, and hit start. Switch between cIEF and CE-SDS applications as much as you want—there's no setup, maintenance needed, so no contamination!

Maurice cartridges

Technology & Applications

cIEF and CE-SDS applications on Maurice

Figure 1.  (A) Charge profiles for four different mAbs using a platform method, 0.15-0.25 mg/mL mAb prepared with 2 M urea, 4% 3–10 Pharmalyte, 10 mM arginine and iminodiacteic acid, pI markers 4.05 and 9.99. (B) Maurice IgG size standard (1 mg/mL) denatured for 10 min at 70 °C under reducing (βME) or non-reducing (IAM) conditions. Reduced IgG was separated for 25 min, non-reduced IgG was separated for 35 min.

Two ways to get data

Maurice gives you IgG purity data in 35 minutes, and identity and charge heterogeneity data in less than 10 minutes flat! So you can develop your cIEF (in fluorescence and absorbance mode) or CE-SDS methods in a day. Yep, even platform methods for multiple molecules! You’ll get the hands-down most reliable and reproducible data day in and day out with either application.

Figure 2.  (A) cIEF separation profiles over 100 injections with peak area CVs consistently less than 4%. 0.25 mg/mL mAb prepared with 4% 3–10 Pharmalyte, 10 mM arginine and iminodiacteic acid, pI markers 4.05 and 9.99. (B) Two alternating replicates of IgG size standards at 1 mg/mL over 24 consecutive injections. Samples were spiked with Internal Standard, reduced and denatured, then separated for 25 min.

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