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Your workhorse station for purity, identity and heterogeneity analysis
Maurice innovates the conventional capillary electrophoresis technology to automate your protein profiling either by protein size or charge. Need cIEF and CE-SDS data for your mAbs, ADCs, vaccines or virus-like particles? Maurice does it all. Just pop in one of the preassembled cartridges, drop in your sample vials or a 96-well plate, and hit start. You will complete method development in a day; and get high-resolution, reproducible data in minutes.
My molecule has complicated charge profiles that are difficult to resolve
Maurice affords high-resolution protein characterization of charge isoforms by preserving our proprietary imaged capillary isoelectric focusing (icIEF) technology, which has been the go-to method for measuring charge heterogeneity. The whole-column detection eliminates the post-focusing mobilization step needed with traditional cIEF, and can resolve your most challenging molecules including fusion proteins and hydrophobic ADCs.
My current cIEF method is not reproducible and error-prone
Maurice employs a prequalified, ready-to-use cartridge design which fully automates column conditioning and clean up. No laborious capillary assembly or maintenance is required. The on-board sample mixing feature further enhances the ease-of-use, and reduces operator-dependent variability commonly encountered with other systems.
I need to use Empower® 3 Chromatography Data Software
The Maurice Empower® Control Kit lets you control Maurice with Empower® 3 software while maintaining 21 CFR Part 11 compliance. Still want to use Compass for iCE software? Our latest embedded software allows you to use both.
Maurice produces pI and charge heterogeneity data in less than 10 minutes, and protein size-based CE-SDS data in 35 minutes. The fast separation time, flexible workflow and high reproducibility makes Maurice a true lab workhorse. In one day you can complete your method development, or analyze 48 to 100 samples in one batch. The icing? You can develop platform methods and use them for multiple molecules too.
I am concerned about cross-contamination between applications
Maurice employs completely separate fluid paths for cIEF and CE-SDS applications. Waste is collected inside the cartridge which removes the concern about cross-contamination between experiments. In addition, when dealing with molecules such as antibody-drug conjugates (ADCs), no more hassle about handling the toxic waste.
My sample is limited and they tend to aggregate at high concentration
Maurice's native fluorescence detection for cIEF provides 3-5X higher sensitivity than UV absorption, which means you can now measure sample at concentration as low as 0.7 µg/ml. And because proteins tend to aggregate less at lower concentrations you can reduce or even eliminate urea completely in some of your methods. Baselines are also significantly cleaner and less sensitive to ampholyte interference, giving you more options when optimizing your pH gradient.
I work in a GMP lab and data integrity is key to my compliance requirement
Compass for iCE, the software package Maurice uses to acquire, manage and analyze data, has all the tools required for 21 CFR compliance so you'll have no issue analyzing biotherapeutics on Maurice in a regulated environment.