Maurice S.

IgG purity and heterogeneity

Maurice S. simplifies your size separations workflow by cutting out all the optimization guesswork. His ready-to-go CE-SDS cartridge gives you IgG purity data in 35 minutes. The best part? Get method development done in a day—platform methods too! Now you can run all your antibodies to get the purity data, heavy and light chain content and HC vs. NGHC composition you need.

Maurice S.

He simplifies your CE-SDS workflow by removing all the set-up and optimization guesswork—it's all done in his ready-to-go cartridge! So you can get purity and heterogeneity data on your mAbs, in 35 minutes. The best part? Method development is such a breeze.

Technology & Applications

CE-SDS on Maurice S.

Figure 1.  Maurice SDS-MW Standard with separation range from 10-240 kDa. Standard was denatured for 5 min at 95 °C under reducing (βME) conditions, then ran using default conditions and separated for 30 min.

Figure 2.  Just pop in a ready-to-go CE-SDS cartridge, drop in your sample vials or a 96-well plate, and hit start—Maurice does the rest!

Bank on your data

Maurice gives you data that's reliable—across samples, users, instruments or labs. We're talking CVs under 2%. Run all your antibodies to get the purity data, heavy and light chain content and HC vs. NGHC composition you need. He's got the high resolution and wide molecular sizing range to handle it all and analyzes your data automatically to boot!

Figure 3.  (A) Maurice IgG size standard (1 mg/mL) denatured for 10 min at 70 °C under reducing (βME) or non-reducing (IAM) conditions. Reduced IgG was separated for 25 min, non-reduced IgG was separated for 35 min. (B) Two alternating replicates of IgG size standards at 1 mg/mL over 24 consecutive injections. Samples were spiked with Internal Standard, reduced and denatured, then separated for 25 min.

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