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Simple Plex for Cell Therapy

Automated Immunoassays for Cell Therapy Process Development

Automated Simple Plex assays on the Ella platform offer high quality immunoassay data and unparalleled efficiency for your cell therapy workflow.

  • Ella reduces the manual operation of an immunoassay by 80 percent. Simply dilute samples and add them to the cartridge.
  • With a total time to result of just 90 minutes, Ella gives you results in a fraction of the time of a manual assay.
  • Sample volume requirements of 25 µL or less and triplicate measurements from every sample well reduce consumption of your precious samples.
  • Measure viral titers, detect process impurities, and characterize transduced cells with Simple Plex assays designed to meet your needs.
Viral titer and immune cell profiling automated assays for cell therapy

Consistent and Reliable

Simple Plex assays on Ella deliver the same data regardless of instrument, operator or location.

  • Volume independent assays that are robust to how much sample is added.
  • Factory calibrated cartridges minimize inter-lot variability allowing you to get the same measurement anywhere.
  • Reduction in manual steps eliminates operator error.

Data from automated ELISA Platform Ella demonstrates low inter-lot variability.

Testing across 3 sites, 11 users and 9 Ella instruments. Four different assays were processed for CCL2, IL-6, TNF α and VEGF-A. Eight unique serum samples with 2 controls for a total of 704 answers.

Solutions for Cell Therapy Manufacturing

The manufacturing of gene modified immune cells is a multistep process that requires rigorous product characterization at various points throughout the workflow. Ella gives you the critical information you need faster, with superior sensitivity and reproducibility that supports regulatory compliance. Accelerate your process development with automated Simple Plex assays for viral titer, process impurity testing, and T cell characterization.


Viral Titer Assays

Accurate detection and quantitative measurement of viral titer in cell cultures is critical for implementation of effective gene transfer treatment strategies. Simple Plex assays are available to quantify viral titers of both lentivirus and adeno associated virus capsids.



Partners in Process Impurity Testing

To bring you the best quality immunoassays, we’ve partnered with the industry leader in bioprocess impurity testing. Cygnus Technologies.

Cygnus Technologies logo

The Simple Plex HEK 293 HCP 3G Assay

The Simple Plex HEK 293 HCP 3G (SPCKB-OT-007066) assay on Ella offers broad detection coverage of the most relevant host cell proteins (HCPs). Ella delivers excellent sensitivity and extended dynamic range to ensure precise sample detectability at each stage of the purification process. The assay is based on the same antibodies currently used in the Cygnus HEK 293 HCP ELISA kit, 3G Resupply 1 (F650S). As a result, you get the same accuracy and consistency you would expect from the Cygnus ELISA, but with an automated, streamlined workflow. The Simple Plex HEK 293 HCP 3G assay is available for purchase directly from Cygnus Technologies.

Simple Plex HEK 293 HCP 3G Specs
LLOQ 1.64 ng/mL
ULOQ 400 ng/mL

Download HEK 293 HCP 3G Spec Sheet

Ella Cygnus CHO HCP page

How Does the Simple Plex HEK 293 HCP 3G Assay Compare with the Cygnus ELISA?

In this application note, we demonstrate assay comparability between the Simple Plex HEK 293 HCP 3G assay and the Cygnus HEK 293 HCP ELISA 3G Resupply 1 ELISA to show that you get the same high-quality data you would expect from the Cygnus ELISA with an automated, streamlined workflow.


Multianalyte Measurements for Immune Cell Characterization

Multianalyte cartridges on Ella allow you to take multiple biomarker measurements in parallel rather than in multiplex. This ensures the highest quality data since all assays are run in a discrete environment. Combine any four analytes from our menu into a custom panel for your immune cells.

T cell characterization on automated ELISA system Ella

See the full Simple Plex assay menu, learn more about how Ella works or talk to one of our Immunoassay specialists about Cell and Gene Therapy solutions for your lab.

Bio-Techne's Tools for Cell and Gene Therapy Development

Bio-Techne offers a diverse portfolio of products and services designed to accelerate and simplify your cell and gene therapy workflow. From GMP proteins and small molecules to state-of-the-art analytical instrumentation, Bio-Techne is committed to providing high quality innovative solutions. Learn more about Bio-Techne’s cell and gene therapy offerings.

Simple Plex Applications


COVID-19 Research Multiplex Assays


Inflammation Research Assays


Cancer Research Multiplex Assays


Neuroscience Research Multiplex Assays


Cell Therapy

Cell Therapy Research Multiplex Assays

Bioprocess Dev.

Bioprocess Development Multiplex Assays

Preclinical Res.

Simple Plex for Preclinical Research

Viral Titer Assay

Viral titer assays on automated ELISA system Ella
Other Simple Plex Products

Single analyate, multi-analyte, and multiplex assay options for automated ELISA system Ella

  16x1 32x1 16x2 16x3 16x4 32x2 72x1 32x3 32x4 32x5 32x6 32x7 32x8
Samples 16 32 16 16 16 32 72 32 32 32 32 32 32
Plex 1 1 2 3 4 2 1 3 4 5 6 7 8
Replicates 3 3 3 3 3 3 3 3 3 2 2 2 2
Reportable Results 16 32 32 48 64 64 72 96 128 160 192 224 256

Single Plex

Single Plex cartridge


Multianalyte cartridge


Multiplex cartridge


Customizable cartridge


Stocked cartridges