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Simple Plex for Inflammatory Biomarkers

Next Gen Immunoassays for Immune Reactivity and Inflammation Research

The systemic cytokine and chemokine cascades set off by acute inflammatory responses require a fast, sensitive and standardized immunoassay format to profile accurately. Automated Simple Plex™ assays on Ella™ get you that critical immune reactivity information and inflammation status data by simply adding your sample and buffers to a cartridge and pressing Start.

Whether you're a researcher tackling cytokine release syndrome, sepsis, the pertinent COVID-19 pandemic, or other acute respiratory failure research, reliably monitoring the inflammatory response is the crux of your ability to make informed decisions. And Ella delivers the results you need, fast.

Real-Time, Standardized Biomarker Profiling

  • With a total time to result of just 90 minutes, Ella gives you readouts in a fraction of the time of a manual assay
  • Ella ensures the standardization of your immunoassay, as everything is exclusively pre-packaged, pre-optimized, and pre-loaded
  • With a four-log range of detection, Simple Plex assays have the sensitivity to pick up even very low picogram-per-milliliter levels of endogenous analyte

Ella Promises Better Clinical Care for Acute Respiratory Failure and Sepsis

"Timely results from Ella have the potential to direct treatment for acute diseases where administration needs to take place in a matter of hours."

- Michael Matthay, M.D., Ph.D., Professor of Medicine, University of California San Francisco

Simplifying and Expediting Inflammatory Biomarker Research with Ella

"Ella is the closest I’ve seen to my goal of one day having a Star Trek-like tricorder. I can take just 25 μL of serum, add it to a cartridge, and in 90 minutes have immune profiling data."

- E. Scott Halstead, M.D., Ph.D., Associate Professor, Department of Pediatrics, Penn State University College of Medicine

Ella Characterizes Cytokine Release Syndrome Biomarkers in CAR T-cell Therapy

Correlating biomarkers with clinical evidence is essential for the safe delivery of CAR T-cell therapies, and, therefore, for the full realization of their therapeutic potential. To do this, fast and accurate evaluation and monitoring of the immune response is necessary. Download this poster to see how researchers at Moffit Cancer Center use Ella to quantitate relevant biomarker levels in the serum of CAR T donors compared with healthy controls.

Fast and Reproducible Quantitation of Cytokines with Ella

Manual immunoassay workflows are error-prone and struggle with reproducibility and variability of results—results that take hours of time to produce and analyze. Not with Ella. Download this application note for a glimpse of peer-reviewed work from researchers around the globe using Ella to reliably and quickly measure cytokines.

More of Simplex Plex in the Inflammation Research Literature

Learn how Ella is already advancing inflammatory biomarker research.

Simple Plex Assays for Inflammation

These analytes are key for monitoring immune reactivity and have been implicated in acute inflammatory responses to pathologies such as cytokine release syndrome, sepsis, COVID-19, and acute respiratory distress syndrome. For a look at our exclusive COVID-19 panel and package, click here.

The Industry Leader in Quality

Simple Plex assays are developed by the industry leader in immunoassays, R&D Systems, so you know a high level of quality and validation is behind Ella, and will provide you with the analytical power and assay sensitivity needed to support your inflammation research.

  • Brought to you by the makers of Quantikine® ELISA kits, Simple Plex assays continue a legacy of quality immunoassays
  • Our vertically integrated supply chain ensures you get the same results years into the future


Browse the full Simple Plex assay menu, see how Ella works, or talk to one of our Immunoassay specialists about inflammatory biomarker assay solutions for your lab.


Simple Plex Applications


COVID-19 Research Multiplex Assays


Inflammation Research Assays


Cancer Research Multiplex Assays


Neuroscience Research Multiplex Assays


Cell Therapy

Cell Therapy Research Multiplex Assays

Bioprocess Dev.

Bioprocess Development Multiplex Assays

Preclinical Res.

Simple Plex for Preclinical Research

Viral Titer Assay

Viral titer assays on automated ELISA system Ella
Other Simple Plex Products

Single analyate, multi-analyte, and multiplex assay options for automated ELISA system Ella

  16x1 32x1 16x2 16x3 16x4 32x2 72x1 32x3 32x4 32x5 32x6 32x7 32x8
Samples 16 32 16 16 16 32 72 32 32 32 32 32 32
Plex 1 1 2 3 4 2 1 3 4 5 6 7 8
Replicates 3 3 3 3 3 3 3 3 3 2 2 2 2
Reportable Results 16 32 32 48 64 64 72 96 128 160 192 224 256

Single Plex

Single Plex cartridge


Multianalyte cartridge


Multiplex cartridge


Customizable cartridge


Stocked cartridges