Simple Plex for Neurofilament Research
and other Neuroscience Biomarkers
Simple Plex Assays for Neuroscience
With immunoassays developed by industry leader R&D Systems, Ella gives you the data you need to power your neuroscience research with a high level of automation, validation and reliability.
Highly Sensitive and Reproducible NF-L Measurements
With the Simple Plex NF-L assay on Ella you get measurements on an automated, robust and reproducible immunoassay platform. In our application note we demonstrate how Ella provides highly reproducible NF-L measurements even at the low levels detected in serum and plasma.
NF-L and NF-H as Important Indicators of Neurodegeneration and Preeclampsia
Neurofilament heavy and light chains are associated with a number of pathological conditions, and both individually and in conjunction are promising better diagnosis and monitoring of a number of diseases. Learn how researchers at Beth Israel Deaconess Medical Center, Harvard Medical School and Cedars-Sinai in collaboration with Bio-Techne are exploring the promise of NF-L and NF-H as biomarkers.
Biomarkers Validated for Cerebrospinal Fluid
Need better biomarker data from your cerebrospinal fluid (CSF) samples? We've got neuroscience biomarker assays that have been fully validated for measurement in CSF. Have precious sample and need to measure multiple biomarkers? Talk to our specialists about creating a custom panel for your research.
|Neuroscience Biomarkers Validated for CSF|
|CD27||IFNg 3rd Gen||NF-H||VCAM-1|
|CXCL10||IL-6 2nd Gen||Procalcitonin|
Simple Plex Neuroscience Biomarker Research in Literature
Learn how researchers are using neurofilament and neuroinflammation biomarker assays on Ella in their research.
- Prion protein lowering is a disease-modifying therapy across prion disease stages, strains, and endpoints
Eric Vallabh Minikel, Hien T Zhao, Jason Le, Jill O’Moore, Rose Pitstick, Samantha Graffam, George A Carlson, Michael P Kavanaugh, Jasna Kriz, Jae Beom Kim, Jiyan Ma, Holger Wille, Judd Aiken, Deborah McKenzie, Katsumi Doh-ura, Matthew Beck, Rhonda O'Keefe, Jacquelyn Stathopoulos, Tyler Caron, Stuart L Schreiber, Jeffrey B Carroll, Holly B Kordasiewicz, Deborah E Cabin, Sonia M Vallabh
Nucleic Acid Research, Aug 2020; 10.1093/nar/gkaa616
- The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer’s Disease
Xavier O. Scott, Marisa E. Stephens, Marie C. Desir, W. Dalton Dietrich, Robert W. Keane, and Juan Pablo de Rivero Vaccari
International Journal of Molecular Sciences, July 2020; 21: 4674.
- Neurofilament as a potential biomarker for spinal muscular atrophy
Basil T. Darras, Thomas O. Crawford, Richard S. Finkel, Eugenio Mercuri, Darryl C. De Vivo, Maryam Oskoui, Eduardo F. Tizzano, Monique M. Ryan, Francesco Muntoni, Guolin Zhao, John Staropoli, Alexander McCampbell, Marco Petrillo, Christopher Stebbins, Stephanie Fradette, Wildon Farwell, Charlotte J. Sumner
Annals of Clinical and Translational Neurology, Mar 2019; 6: 932-944. doi: 10.1002/acn3.779
- Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response
Shariful A. Syed, Eléonore Beurel, David A. Loewenstein, Jeffrey A. Lowell, W. Edward Craighead, Boadie W. Dunlop, Helen S. Mayberg, Firdaus Dhabhar, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari, Charles B. Nemeroff
Neuron, Aug 2018; S0896-6273(18)30674-3. doi: 10.1016/j.neuron.2018.08.001
- Inflammasome proteins as biomarkers of multiple sclerosis
Robert W. Keane, W. Dalton Dietrich, Juan Pablo de Rivero Vaccari
Frontiers in Neurology, Mar 2018; 10.3389/fneur.2018.00135
- Evaluation of highly sensitive immunoassay technologies for quantitative measurements of sub-pg/mL levels of cytokines in human serum
David Yeung, Shawn Ciotti, Shobha Purushothama, Elham Gharakhani, Geoffrey Kuesters, Brian Schlain, Chase Shen, Douglas Donaldson, Alvydas Mikulskis
Journal of Immunological Methods, Oct 2016; 437:53-63. doi: 10.1016/j.jim.2016.08.003